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Sour, bitter, and harsh to the taste, as unripe fruit; sharp and harsh.

To sour; to imbitter; to irritate.

Sour or severe.

Sourness and harshness. [Obs.] Bailey.

Harshness, bitterness, or severity; as, acerbity of temper, of language, of pain. Barrow.

To render more violent or bitter; to irriate; to exasperate; to imbitter, as passions or disease. Broughman.

The act rendering more violent or bitter; the state of being exacerbated or intensified in violence or malignity; as, exacerbation of passion.

Increase of irritation or violence, particularly the increase of a fever or disease.

A remedy possessing the property of preventing the return of periodic paroxysms, or exacerbations, of disease, as in intermittent fevers.

Sour and astringent; rough to the state; having acerbity; as, an austere crab apple; austere wine.

Harshness or astringent sourness to the taste; acerbity. Johnson.

Increase of violence or malignity; aggravation; exacerbation. "Exasperation of the fits." Sir H. Wotton.

h produces convulsions or unconsciousness; a convulsion; a paroxysm; hence, a period of exacerbation of a disease; in general, an attack of disease; as, a fit of sickness. And when the fit was on him, I did mark How he did shake. Shak.

A disease, the chief symptom of which is a very acute pain, exacerbating or intermitting, which follows the course of a nervous branch, extends to its ramifications, and seems therefore to be seated in the nerve. It seems to be independent of any structural lesion. Dunglison.

The fit, attack, or exacerbation, of a disease that occurs at intervals, or has decided remissions or intermissions. Arbuthnot.

The time of the exacerbation and remission of a disease, or of the paroxysm and intermission.