QUINTESSENCE n.
Hence: An extract from anything, containing its rarest virtue, or most subtle and essential constituent in a small quantity; pure or concentrated essence. Let there be light, said God; and forthwith light Ethereal, first of things, quintessence pure, Sprung from the deep. Milton.
RHINOSCLEROMA n.
A rare disease of the skin, characterized by the development of very hard, more or less flattened, prominences, appearing first upon the nose and subsequently upon the neighboring parts, esp. the lips, palate, and throat. J. V. Shoemaker.